Hp重复根除对十二指肠溃疡远期复发率的影响

Effect of Repeat Eradicating Helicobacter Pylori Infection on the Long-term Recurrence of Duodenal Ulcer

目的观察幽门螺旋杆菌(Hp)重复根除对十二指肠溃疡远期复发率的影响。方法将90例Hp感染合并十二指肠溃疡的患者随机分为2组。对照组40例,采用果胶铋、呋喃唑酮、阿莫西林胶囊三联治疗,疗程2周;治疗组50例,治疗同对照组,6个月后重复上述三联治疗。分别在完成治疗后的6、12、18和24个月复查胃镜及Hp检测。结果对照组4个时间段十二指肠溃疡复发率分别为2.5%、10.0%、5.0%、5.0%,总复发率为22.5%;治疗组为0%、2.0%、2.0%、2.0%,总复发率为6.0%。治疗组总复发率明显低于对照组(P<0.05)。结论Hp重复根除能明显降低十二指肠溃疡的远期复发率。

Objective To observe effect of repeat eradicating Helicobacter pylori（Hp）infection on the long-term recurrence of duodenal ulcar（DU）. Methods Ninety patients with DU and concomitant Hp infection were randomly divided into 2 groups：In the control group（n=40） the patients took 3 drugs（colloidal bismuth pectin, furazolidone, amoxicillin） only for 2 weeks, while the patients in treatment group （n=50） did requiredanadditional course 6 months later. Gastroscopy and Hp test were reexamined in 6,12,18,and 24 months later. Results In the control group,recurrence rates were 2.5%,10.0%,5.0% and 5.0%,in 6,12,18 and 24 months,respectively,and accumulative recurrence rate was 22.5%;in 2 years; whereas in treatment group, there currence rates were 0%, 2.0%, 2.0% and 2.0%,respectively,and the accumulative recurrence rate was 6.0%. The long-term recurrence rate in the treatment group was significantly lower than that in the control group （P〈0.05）. Conclusion Rrpeat eradicating Hp infection could reduce markedly the long-term recurrence in patients with DU.