药物粘附技术控制食管静脉曲张破裂出血的研究

Study of Controlling Acute Hemorrhage from Esophageal Varices Using Adhesion Technique of Traditional Chinese Medicine

目的：探索一种方法，使药物粘附于食管腔粘膜，达到局部治疗食管静脉曲张破裂出血的目的。方法：观察３０例健康人于特定条件下直立及卧位时具有粘附力强的中药制剂在食管内通过及滞留情况（部位、时间）。同时对食管曲张静脉玻裂出血的３７例患者，进行了治疗观察。结果：（１）在特定条件下观察到止血中药在食管下部滞留较长的时间，卧位较直立位时间延长更为明显（Ｐ＜０．０１）。（２）口服粘附力强的止血中药对控制食管静脉曲张破裂出血与使用三腔管压迫比较，具有相同疗效（Ｐ＞０．０５）。结论：为食管静脉曲张破裂出血提供了一项新的治疗方法。

Objective: The aim of this study was to find a method making the traditional Chinese medicine adhesiion to the esophageal membrane for controlling bleeding emphageal varices. Methods : The position and time that the medicine attached in the esophagus were observed in 30 healthy volunteers under the condition of erect and lying position.Thirty-seven cases with bleeding esophageal varices were treated by this technique. Results:The medicine of adhesion was attached in the segment of esophagus more than 15 minutes under the condition of lying position . The effective rate of controlling bleeding esophageal varices was no statistical differences between the ballon temponade and our technique(P > 0. 05 ). Conclusions: This technique is a new aPProach to control hemorrhage from esophageal varices.