噻庚啶对失血性休克兔血液流变学的影响

EFFECTS OF CYPROHEPTADINE ON HEMORRHEOLOGY IN RABBITS WITH HEMORRHAGIC SHOCK

将３０只新西兰兔随机分为噻庚啶治疗组和空白对照组各１５只，颈动脉放血复制失血性休克模型。采集休克前、后、输血输液（对照组）和用药（噻庚啶１０ｍｇ／ｋｇ）后６０ｍｉｎ颈动脉血液样本，测定血液流变学四项指标的变化。结果显示，休克后血液流变学四项指标明显低于休克前正常值（Ｐ＜００１），输血输液（全身缺血后再灌注）和用药后上述指标进一步下降，但两组之间无显著性差异（Ｐ＞００５）。本实验表明，兔失血性休克后血流变学指标下降，可能是动物处于代偿阶段，组织液重吸收所致；再灌后由于直接的血液稀释和低分子右旋糖酐的作用，造成血流变学指标更趋降低。噻庚啶对血流变学无明显影响，其抗休克作用主要在于改善心血管和微循环功能。

Thirty rabbits were equally divided into a cyproheptadine (CPH) treated group and a control group. The model of hemorrhagic shock was made and blood samples in rabbits before and 120 minutes after shock, and 60 minutes after liquid and blood infusion and administering CPH (10mg/kg) were collected from the carotid artery. Four indexes of hemorrheology were determined. The results showed that four indexes of hemorrheology after shock were significantly lower than those before shock (P<0 01). Although the indexes after blood and liquid infusion (reperfusion) were further reduced, compared with those 120 mimutes after shock, the differences were not significant (P>0 05). Compared with the control group,the hemorrology in rabbits of CPH treated group did not change obviously (P>0 05). This experiment indicates that the hemorrheological indexes in rabbits after hemorrhagic shock were decreased. The reason may be that the animals were in the compensatory phase.