突眼性甲状腺疾病病人外周血T淋巴细胞IL-2s、CTLA-4表达的研究

Investigation on the Expression Level of IL-2,sCTLA-4 of Peripheral Blood T Lymphocyte in Patients with Graves,Disease

[目的]探讨抗甲状腺药物（ATD）治疗前后白细胞介素2（IL-2）调节突眼性甲状腺疾病（GD）病人外周血可溶性细胞毒性T淋巴细胞相关抗原4（sCTLA-4）表达的变化，为进一步研究GD病人的治疗对机体免疫功能的影响提供依据。[方法]2006年9月，对2000-2005年在山东省千佛山医院门诊及住院的72例GD患者和健康对照20人进行外周血淋巴细胞IL-2、sCTLA-4、FT3、FT4、TSH的检测。[结果]GD患者中经过药物治疗的甲状腺功能缓解组外周血FT3、FT4、sCTLA-4水平均低于未治疗的甲亢组，TSH、IL-2平均水平高于甲亢组（P〈0．05）；缓解组FT3、FT4、TSH、IL-2、sCTLA-4水平均接近对照组（P〉0．05）；甲亢组FT3、FT4、sCTLA-4水平均高于对照组，TSH、IL-2水平均低于对照组（P〈0．01）。[结论]抗甲状腺药物治疗可调节机体细胞因子的分泌水平，改善机体的免疫功能。

[Objective]To investigate the Expression level of peripheral blood T lymphocyte of IL-2, sCTLA-4 in patients with Graves, disease before and after treatment by ATD, provide scientific basis for studying the improvement of immunological function. [Methods]In September 2006, the expression level of FT3, FT4, TSH, IL-2, sCTLA-4 of peripheral blood was tested for 72 inpatients and outpatients with Graves, disease and 20 healthy people in control group in Qianfushan hospital from 2000 to 2005. [Results]The expression level of FT3, FT4, sCTLA-4 in relief group was lower than the patients with hyperthyreosis , but TSH, IL-2 level was higher than hyperthyreosis group （ P〈0.05） ;The expression level of FT3, FT4, TSH, IL-2, sCTLA-4 of relief group was near about control group （ P〉0.05） ; FT3, FT4, sCTLA-4 level of hyperthyreosis group was higher than control group, but TSH、IL-2 expression was lower than control group. [Conclusion]Secretion level of cytokines may be regulated after ATD treatment , the body＇s immunological function can be improved.