丝氨酸蛋白酶Omi／HtrA2与细胞凋亡
Serine protease Omi/HtrA2 and apoptosis
摘要
Omi／HtrA2是一种定位于线粒体膜间隙的丝氨酸蛋白酶，是一种凋亡调节因子，释放到线粒体外参与细胞凋亡。它有双重功能：一方面阻止X染色体连锁凋亡抑制蛋白，促进caspasc级联反应；另一方面作为丝氨酸蛋白酶诱导非caspase依赖的细胞凋亡。该文介绍了Omi／HtrA2的结构、体内分布以及参与细胞凋亡的机制和在相关疾病中的作用。
出处
《国际儿科学杂志》
2008年第4期308-310,共3页
International Journal of Pediatrics
基金
四川省杰出青年学科带头人培养基金资助项目（04ZQ026-033）
参考文献16
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