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骨形态生成蛋白信号传导与肺脏关系的研究进展 被引量：2

Progress of relationship between signal transduction of bone morphogenetic protein and lung
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摘要 骨形态生成蛋白（BMP）是一种具有广泛生物学活性的多功能细胞因子，其信号传导主要通过丝氨酸／苏氨酸激酶受体和Smads蛋白实现。近年发现BMP不仅是多功能的分泌蛋白，更是脊椎动物发育的关键信号分子。BMP信号通路参与调控胚胎肺发育，并与多种肺疾患如原发性及缺氧性肺动脉高压、肺纤维化、支气管肺发育不良以及肺癌等密切相关。BMP信号传导与肺脏关系是近年来研究的新热点，该文简要介绍BMP信号传导机制，并初步探讨BMP信号通路在胎肺发育和部分肺疾患中的作用。
作者 陈筱青(综述) 周晓玉(审校)
机构地区 江苏省妇幼卫生保健中心 南京医科大学附属南京儿童医院
出处 《国际儿科学杂志》 2008年第4期369-372,共4页 International Journal of Pediatrics
关键词 骨形态发生蛋白质类 肺脏 临床研究 多功能细胞因子
分类号 R683 [医药卫生—骨科学] R563 [医药卫生—呼吸系统]
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参考文献22

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  • 2Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signaling. Nature, 2003,425 (6958) : 577-584.
  • 3Morrell NW. Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling? Proc Am Thorac Soc, 2006, 3 (8) : 680- 686.
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同被引文献71

  • 1Urist MR. Bone:formation by autoinduction[J].Science,1965,(06):893-895.
  • 2Bragdon B,Moseychuk O,Saldanha S. Bone morphogenetic proteins:a critical review[J].Cellular Signalling,2011,(04):609-620.
  • 3Weber S,Taylor JC,Winyard P. SIX2 and BMP4 mutations associate with anomalous kidney development[J].Journal of the American Society of Nephrology,2008,(05):891-903.doi:10.1681/ASN.2006111282.
  • 4Ueda H,Miyazaki Y,Matsusaka T. Bmp in podocytes is essential for normal glomerular capillary formation[J].Journal of the American Society of Nephrology,2008,(04):685-694.doi:10.1681/ASN.2006090983.
  • 5Suzuki J,Otsuka F,Matsumoto Y. Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys[J].Hypertension Research,2012,(03):312-317.
  • 6Tominaga T,Abe H,Ueda O. Activation of bone morphogenetic protein 4 signaling leads to glomemlosclerosis that mimics diabetic nephropathy[J].Journal of Biological Chemistry,2011,(22):20109-20116.
  • 7Ninomiya N,Michiue T,Asashima M. BMP signaling regulates the differentiation of mouse embryonic stem cells into lung epithelial cell lineages[J].In Vitro Cellular & Developmental Biology-Animal,2013,(03):230-237.
  • 8Xu B,Chen C,Chen H. Smadl and its target gene Wifl coordinate BMP and Wntsignaling activities to regulate fetal lung development[J].Development,2011,(05):925-935.
  • 9Pegorier S,Campbell GA,Kay AB. Bone morphogenetic protein(BMP)-4 and BMP-7 regulate differentially transforming growth factor(TGF)-β1 in normal human lung fibroblasts (NHLF)[J].Respiratory Research,2010.85.
  • 10Li X,Lu W,Fu X. BMP4 increases TRPC protein expression by activating p38MAPK and ERK1/2 signaling pathways in PASMC[J].American Journal of Respiratory Cell and Molecular Biology,2013,(02):212-220.

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国际儿科学杂志
2008年 第4期

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