青年人膀胱癌细胞P53基因蛋白表达的流式分析

EXPRESSION OF P53 PROTEIN IN BLADDER TRANSITIONAL CELL CARCINOMA OF YOUNG PEOPLE BY FLOW CYTOMETRY

采用流式细胞术和细胞免疫荧光技术，对１３例青年人膀胱移行细胞癌Ｐ５３蛋白表达和ＤＮＡ倍体进行分析，结果表明：Ｐ５３表达与病人年龄密切相关，４０岁以下青年人膀胱移行细胞癌的预后明显优于４０岁以上患者（Ｐ＜００１）。结合Ｐ５３表达和ＤＮＡ倍体对预后作了综合分析，提示：青年人膀胱移行细胞癌为低度恶性，预后良好。

P53 expression and DNA ploid were quantitatively examined in 13 cases of bladder transitional cell carcinoma in young people (under 40 years of age) by flow cytometry and cytoimmunofluoresence using monoclonal anti-body PAb1801. The results showed that P53 expression was closely associated with age and that the prognosis of the young patients was obviously superior to that of the older that ones above 40 years of age,P<0 01). The research suggests that the malignancy of the cancer in young people was low and the patients have a good prognosis according to P53 expression and DNA ploid analysis.