摘要
目的:探讨原发性甲状腺功能减退症(原发性甲减)患者血清泌乳素(PRL)水平在甲状腺激素替代治疗前后的变化。方法:选择原发性甲减女性患者41例,观察在甲状腺激素替代治疗前后,血清PRL、TSH、FT3、FT4水平变化,探讨原发性甲减患者中甲状腺激素替代治疗前后PRL水平变化的意义。结果:治疗前PRL升高者14人,占原发性甲减患者的34·1%,PRL升高者中有5例伴有乳溢。经过甲状腺激素替代治疗,PRL显著下降(P<0·01)。结论:部分原发性甲减患者存在高PRL血症,伴有或不伴有乳溢,经过甲状腺激素替代治疗后血清PRL水平降至正常水平,乳溢症状消失。
Objective :To study the changes of prolactin level of the patients with primary hypothyroidism before and after thyroid hormones replacement treatment.Methods:The PRL、TSH、FT3、FT4 were measured in 41 female patients with primary hypothyroidism before and after thyroid hormones replacement treatment to explore the explanations for the relationship between the treatment and changes of PRL.Results:Before the treatment, PRL of 14 patients was high, which is 34.1% of the total patients.5 in the 14 patients had galactorrhea.The PRL level significantly decreased after thyroid hormones replacement treatment and the symptom of galactorrhea disappeared(P<0.01).Conclusion:Hyperprolactinemia in some patients with primary hypothyroidism with galactorrhea or not can be cured by thyroid hormones replacement, and PRL can be returned to the normal level.
