120例2型糖尿病大血管病变血浆中纤维蛋白原及D-二聚体水平分析

Evaluation of plasma fibrin and D-dimer levels in 120 type 2 diabetes mellitus patients with macrovascular compilations

目的分析成人2型糖尿病及其大血管病变患者的血浆纤维蛋白原及D－二聚体检测水平，探讨血浆纤维蛋白原及D－二聚体与2型糖尿病及其大血管并发症的关系。方法2型糖尿病患者120例，按有无大血管并发症分为2组，单纯糖尿病组51例，糖尿病并发大血管病组69例。30例健康查体者作为对照纽。所有受试者均进行血浆纤维蛋白原及D－二聚体的检测。结果血浆纤维蛋白原测定：单纯糖尿病组、糖尿病并发大血管病组与对照组比较均有统计学意义（均P〈0．05），糖尿病并发大血管病组与单纯糖尿病组比较无统计学意义（P〉0．05）；D－二聚体测定都增高，单纯糖尿病组与对照组比较有统计学意义（P〈0．01），糖尿病并发大血管病组与对照组比较有统计学意义（P〈0．01），糖尿病并发大血管病组与单纯糖尿病组比较有统计学意义（P〈0．01）。结论2型糖尿病患者血浆纤维蛋白原水平都增高，但与有无并发症及其病程无关；D－二聚体的明显增高提示D－二聚体与大血管并发症之间的密切关系。

Objective To evaluate the plasma fibrin and D-dimer levels in patients with macrovascular complication in type 2 diabetes and to investigate the association between plasma fibrin and D-dimer level and macrovascular compilations in type 2 diabetes mellitus. Methods One hundred and twenty patients hospitalized with type 2 diabetes were divided into two groups based on whether they have macrovascular complications. 30 healthy people were enrolled into control group. Results All patients were evaluated for plasma fibrin and D-dimer level in type 2 diabetes mellitus. Plasma D-dimer level in type 2 diabetes mellitus with macrovascular compilations was higher than in type 2 diabetes mellitus without macrovascular complications. Conclusions These results suggest that D-dimer play an important role in the pathogenesis of macrovascular complications.