3种革兰阳性球菌耐药性与头孢噻肟、红霉素用药频度的相关性分析

Analysis of the relationship between use frequency of Cefotaxime,Erythromycin and changes of drug-resistance of three kind Gram+ coccus

目的调查金黄色葡萄球菌、无乳链球菌、粪肠球菌分别对头孢噻肟、红霉素耐药性,及以上两药用药频度,探讨用药频度和耐药性之间的相关性。方法回顾性分析,收集2002-2006年3种球菌药敏试验资料及两药使用量,计算出耐药率和两药的用药频度(DDDs),对耐药率与用药频度进行相关性分析。结果金黄色葡萄球菌、无乳链球菌、粪肠球菌对头孢噻肟耐药率增幅分别为16.2%、9.0%、12.6%,对红霉素耐药率增幅分别为13.7%、10.0%、9.6%;3种球菌耐药率变化对头孢噻肟用药频度呈显著正相关(r分别为0.92、0.90、0.92,P≤0.05),对红霉素用药频度相关性没有统计学意义(r分别为0.42、0.57、0.52;P>0.05),红霉素用量呈下降趋势,但耐药率仍呈增长。结论3种球菌对头孢噻肟、红霉素的耐药率全部呈增长趋势,耐药率变化对头孢噻肟用药频度呈显著正相关,对红霉素用药频度相关性无统计学意义。

Ohjective To investigate the drug-resistance of StaPhylococcus aureus,Streptococcus agalactiae ,Enterococcus faecalis for Cefotaxime,Erythromycin and this drug use frequency from yearly from 2002 to 2006 and analyze the correlation between them. Methods By prospective study, to collect drug sensitive test three kind Gram ＋ coccus from 2002-2006 and usage amount of Cefotaxime,Erythromycin. to count Drug resistance Rate and drug use frequency by WHONET 5.3 and EXCEL. gave correlation of usage amoun and drug use frequency. Results In 5 years,Drug resistance rate of three kind Gram ＋ coccus for Cefotaxime,Erythromycin grow trend. The rate of increase of StaPhylococcus aureus ,Streptococcus agalactiae ,Enterococcus faecalis for Cefotaxime is 16.2% ,9.0% ,12.6% ,for Erythromycin is 13.7% ,10. 0% ,9. 6%. amount of usage Erythromycin show descend, but Drug resistance rate show grow trend yet. Conclusion The drug resistance rate of three kind Gram ＋ coccus for Cefotaxime,Erythromycin show grow trend. The Drug resistance rate change was correlated with use frequency of Cefotaxime,was not correlated with use frequency of Erythromycin.