子宫内膜间质肉瘤多成分分化与临床生物学特性的关系

Study on the relationship between clinical-biological significance and multiple component differentiation in Endometrial Stromal Sarcomas

目的探讨子宫内膜间质肉瘤（ESS）多成分分化与临床生物学特性的关系。方法运用组织病理学、免疫组织化学及Masson特染分析24例低度恶性子宫内膜间质肉瘤（LGESS）和12例未分化子宫内膜肉瘤（UES）的临床病理资料。结果LGESS、UES两组中性索分化分别为37，5％（9／24）、83，3％（10／12），差异有统计学意义（P〈0.05）；两组平滑肌分化均为33.3％，纤维分化为29.2％、33.3％，上皮样分化为12．5％、16．7％，无统计学意义。结论ESS可伴多成分分化，主要为性索、平滑肌和纤维分化；预后可能与性索成分有关，而与其他成分无关。

Objective To study the relationship between clinical-biological significance and multi-differentiation in Endometrial Stromal Sarcomas（ESS）. Methods 24 cases of low grade ESSs （LGESS） and 12 cases of undifferentiated Endometrial sarcomas （UES） were studied by histopathology immunohistochemical method, histochemical method, and clinical follow-up. Results Among the 24 cases of LGESSs, there were 9 cases with sex-cord differentiation, 8 cases with smooth muscle differentiation,7 cases with fibrous differentiation,and 3 cases with epithelial differentiation. Among the 12 cases of UESs, there were 10 cases with sex-cord differentiation,4 cases with smooth muscle differentiation,4 cases with fibrous differentiation, and 2 cases with epithelial differentiation. There was positive correlation of sex-cord differentiation between LGESS and UES（ P 〈 0. 05 ）. Conclusion ESS can display multi-differentiation. Sex-coed, fibrous and smooth muscle differentiation, the most common types. There might be correlation between prognosis and the amount of sex-cord component and no definite correlation of other multi-differentiation components.