复苏饮对重症脑出血患者血清TNF-α、IL-1、IL-6影响的临床研究

The clinical research on the effect of FuSuyin on Inflammatory cytokine TNF-α、IL-1、IL-6 in severe cerebral hemorrhage patients

[目的]观察复苏饮对重症脑出血患者血清炎症细胞因子TNF-α(肿瘤坏死因子-α)、IL-1(白细胞介素-1)、IL-6(白细胞介素-6)释放的影响作用。[方法]根据双盲随机试验的方法将入住icu的重症脑出血患者随机分为2组,对照组(131例)和中药组(140例)。对照组给予传统的西医治疗方法脱水、降颅压、止血等,中药组是在此基础上加用复苏饮。在治疗前及治疗后的48h检测TNF-α、IL-1、IL-6的含量,比较治疗前后炎症因子的变化差异。[结果]两组炎症因子在用药前后都有下降,但程度不同,以中药组下降明显,两组差异比较有统计学意义。[结论]复苏饮可以降低重症脑出血患者在急性期的炎症因子释放,从而对脑出血有良好的治疗作用。

[ Objective ] To investigate the effect of FuSuyin Pills on Inflammatory cytokine for exampal TNF - α and IL - 1 contents in grave cerebral hemorrhage patients, [ Methods ] one hundred - senvety one grave cerebral hemorrhage patientsdivided at random into two groups：control group and the traditional Chinese medicine group, treatcontrol group with Western medical theray, while the traditional Chinese medicine group with Western medical theray and FuSuyin, Inflammatory cytokine（ TNF-α, IL - 1 ,IL- 6） were determined before treatment and 48 hour after treatment. [ Results ] Compared with control group, FuSuyin could significantly dcrease the levels of Inflammatory cytokine（ TNF - α, IL - 1, IL- 6）. So we can conclude that decrease the content of Inflammatory cytokinein ischemia--reperfusion iniury patients in good effect on grave cerebral hemorrhage.