医院感染革兰阴性杆菌菌群分布及耐药性调查

Investigation of G^- Pathogens Distribution and Antibiotic Resistance in Hospital Acquired Infection

目的:了解医院感染革兰氏阴性杆菌菌群分布及耐药性。方法:对我院2005年1月至2007年12月临床分离致病菌,采用法国梅里埃ATB expression细菌鉴定仪鉴定,按NCCLS标准进行纸片扩散法药物敏感试验。结果:2005年1月至2007年12月3年中分离致病菌1438株,其中革兰氏阴性杆菌664株,占46.2%;革兰氏阳性菌553株,占38.5%。在革兰氏阴性杆菌中,大肠埃希氏菌191株,占28.8%;肺炎克雷伯菌140株,占21.2%;铜绿假单胞菌135株,占20.4%;阴沟肠肝菌27株,占4.2%;奇异变形杆菌25株,占3.8%。亚胺培南的敏感性最高,其次是哌拉西林/他唑巴坦。结论:应注意合理使用抗生素,并加强对细菌耐药性的全面监测。

Objective： To investigate the distribution drug resistance of G^- pathogens isolated from patients of hospital acquired infection. Methods：The pathogens were isolated and cultured from the strains were tested by ATB expression. Results： 1438 pathogens were isolated. Among them ,664 （46.2%） were G^- b, 553 （38.5%） were G^- c. The majority were escherichiacoli, klebsiella pneumoniae p. aeruginosa, e. cloacare and p. mirabilis. Imipenem and piperacillin-tazobactam were considered effective. Conclusion ： Reasonable use of antibiotics should be taken and study the trend of drug resistance.