摘要
细胞周期是由周期依赖激酶(CDK)和细胞周期蛋白共同作用而完成。尤其是G1期过渡到S期受细胞周期负调节因子家族周期蛋白依赖激酶抑制因子(CDKI)的调节,p21可以和p53共同构成细胞周期G1检查站,因DNA损伤后不经过修复则无法通过,减少受损DNA的复制和积累,从而发挥抑癌作用。当p21、Cyclin、CDK,PCNA四聚体的功能受到抑制,则使增殖信号大量活化,导致细胞异化和恶变。p21作为一种负性调节因子,在依赖野生型p53的表达通路上与肿瘤的表达、表达含量、表达位置,以及预后都密切相关。
Cell cycle is regulated by interaction between Cyclin2 dependent kinase and cell cyclin. Especially,the cell cytle from G1 phase to S phase was regulated by cyclin-dependent kinase inhibitors （ negative growth factor） ,and p21 and p53 is composed of the checkpoint of cell cycle G1 phase. Because the damaged DNA can not be duplicated again without repair,Reducing the dupulication and accumulation of damaged DNA is the method to inhibit cancer. When the tetrameric function of p21 ,Cyclin,CDK,PCNA was inhibited,the quantity of activation of proliferation signals will result in the cell heterization and canceration. As a negative regulator, p21 is closely related to the cancer expression, expression content, expression location and prognosis during the expression pathway of dependent wild type p53.
出处
《医学综述》
2008年第14期2094-2097,共4页
Medical Recapitulate
