坎地沙坦酯治疗高血压合并早期糖尿病肾病的临床研究

Clinical study of candesartan cilexetil in the treatment of diabetic nephropathy associated hypertension

目的观察坎地沙坦酯治疗高血压合并早期糖尿病肾病的疗效。方法选择50例高血压合并早期糖尿病肾病患者,在常规降糖药物治疗同时应用坎地沙坦酯4～12mg/d,12周后比较治疗前后血压、尿微量白蛋白、血尿素氮、血肌酐、血糖、糖化血红蛋白等的变化。结果治疗后,收缩压和舒张压明显降低(P<0.01),尿微量白蛋白显著减少(P<0.05)。结论坎地沙坦酯能够在有效控制血压的同时降低尿微量白蛋白的排泄,对于高血压合并早期糖尿病肾病患者的肾脏具有保护作用。

Objective To observe the curative effect of Candesartan Cilexetil in patients of inchoate diabetic nephropathy with hypertension. Methods 50 patients with inchoate diabetic nephropathy complicated with hypertension all accepted routine diabetic therapy and were given Candesartan Cilexetil 4 - 12 mg/d, to compare and analyze the changes of blood pressure, urine albumin excretion rate, blood urea nitrogen, serum creatinine, blood glucose, HbAlc were measured before and 12 weeks after the treatment. Results After treatment, the blood pressure level in declined significantly（P 〈 0.01 ） , mean microdosis urinary album in decreased obviously compared with that before treatment （ P 〈 0.05）. Conclusion The treatment of Candesartan Cilexetil can lower the blood pressure and decrease urinary albumin , has an effect to protect renal function of diabetic nephropacothy with hypertension patients.