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颗粒酶B在病毒性心肌炎发病机制中作用的研究 被引量：2

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摘要 细胞毒性T淋巴细胞（cytotoxic T lymphocyte，CTL）介导的细胞毒性作用被认为是病毒性心肌炎（viral myocarditis，VMC）中心肌细胞损伤的主要机制之一。CTL通过穿孔素／颗粒酶介导的细胞毒途径、Fas／FasL诱导的细胞凋亡途径及细胞因子介导途径发挥杀伤作用，其中穿孔素／颗粒酶介导的细胞毒途径是CTL识别和清除病毒感染细胞的主要途径。尽管穿孔素能损伤细胞膜致细胞溶解，
作者 郭春艳 韩波
机构地区 山东大学附属省立医院小儿心脏科
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2008年第6期508-509,共2页 Chinese Journal of Microbiology and Immunology
基金 山东省医药卫生科研项目（CAIDBAⅡ）
关键词 病毒性心肌炎 细胞毒性T淋巴细胞 发病机制 颗粒酶B LYMPHOCYTE Fas/FasL 心肌细胞损伤 细胞毒性作用
分类号 R542 [医药卫生—心血管疾病]
  • 相关文献

参考文献5

  • 1叶春华,程志清.颗粒酶与病毒性心肌炎[J].心血管康复医学杂志,2004,13(6):596-598. 被引量：4
  • 2田静,杨英珍,封启明,鲍伟胜.原位杂交法检测颗粒酶B在柯萨奇B3病毒性心肌炎小鼠心肌浸润细胞中的表达[J].上海医科大学学报,2000,27(1):42-44. 被引量：9
  • 3Vermijlen D, Froelich C J, Luo D, et al. Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells. Cancer Immunol Immunother, 2001, 50(4) : 212-217.
  • 4Adrain C, Murphy BM, Martin SJ. Molecular ordering of the caspase activation cascade initiated by the cytotoxie T lymphocyte/natural killer (CTL/NK) protease granzyme B. J Biol Chem, 2005, 280(6) : 4663-4673.
  • 5Waterhouse N J, Sedelies KA, Browne KA, et al. A central role for Bid in granzyme B-induced apoptosis. J Biol Chem, 2005, 280 (6) : 4476-4482.

二级参考文献29

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共引文献10

同被引文献25

  • 1马伏英,智光,樊毫军.栀子等中药抑制柯萨奇B3病毒的体外实验研究[J].新乡医学院学报,2006,23(1):33-35. 被引量：13
  • 2朱艳萍,韩波,韩秀珍,杨巧芝,吕学云,孙文英,秦道刚.颗粒酶B和可溶性Fas配体在病毒性心肌炎血清中的表达与心脏超声心功能的关系[J].实用儿科临床杂志,2006,21(13):817-818. 被引量：4
  • 3郭春艳,韩波.细胞毒性T淋巴细胞抗病毒感染作用机制的研究进展[J].中华儿科杂志,2007,45(2):155-157. 被引量：3
  • 4Shi L, Mai S, Israels S,et al. Granzyme B (GraB) autonomously crosses the cell membrane and PFP initiates apoptosis and GraB nuclear localization [ J ]. J Exp Med, 1997,185 (5) : 855 - 866.
  • 5Heusel JW, Wesselschmidt RL, Shresta S, et al. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells [ J ]. Cell, 1994,76 ( 6 ) : 977 - 987.
  • 6Pardo J, Wallich R, Martin P, et al. Granzyme B - induced cell death exerted by ex vivo CTL: Discriminating requirements for cell death and some of its signs [ J ]. Cell Death Differ,2008,15 ( 3 ) :567 - 579.
  • 7Meslin F,Thiery J, Richon C, et al. Granzyme B - induced cell death in- volves induction of p53 tumor suppressor gene and its activation in tumor target cells[ J ]. Biol Chem ,2007,282 (45) :32991 - 32999.
  • 8Waterhouse N J, Sedelies KA, Trapani JA. Role of Bid - induced mito- chondrial outer membrane permeabilization in granzyme B - induced apoptosis [ J ]. lmmunol Cell Biol,2006,84 ( 1 ) : 72 - 78.
  • 9Ko YH,Park S,Jin H,et al. Granzyme B leakage - induced apoptosis is a crucial mechanism of cell death in nasal - type NK/T - cell lymphoma [ J ]. Lab Invest, 2007,87 ( 3 ) :241 - 250.
  • 10Trapani JA,Jans P,Smyth MJ,et al. PFP -dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction [ J ]. Cell Death Differ, 1998,5 (6) :488 -496.

引证文献2

二级引证文献8

中华微生物学和免疫学杂志
2008年 第6期

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