摘要
目的:研究淀粉样变肾病的病理变化及其临床意义。方法:对2 135例肾穿标本有淀粉样变肾病73例(3.42%)。进行光镜、免疫荧光和电镜观察并分析其临床关系。结果:继发性居多72.6%,其中移植肾2例。艾滋病(AIDS)2例。蛋白尿是主要症状(61/73),与肾小球基膜淀粉样沉积物密切相关(P<0.01)。光镜及免疫荧光观察病变常不典型,但电镜下,所有病例均可见特征性淀粉样纤维丝结构。结论:可疑病例应做肾穿活检,电镜是诊断依据。肾小球基膜淀粉样沉积物和病变是蛋白尿的主要形态学基础。移植肾和艾滋病有可能继发肾淀粉样变,应高度重视。
Objective: To study pathological changes and clinical significance of renal amyloidosis. Methods: 73 (3.42%) patients with renal amyloidosis from 2 135 kidney needle biopsy specimens were studied by light microscopy(CM), immunofluoreseence(IFM) and electron microscopy(EM). Results: Secondary amyloidosis was a common mode of presentation(72.6% ), and of these 73 cases, 2 cases of kidney transplant and 2 cases of AIDS were seen. Proteinuria (61/73) was closely correlated to amyloid deposits in glomerular basement membrane(P<0.01). There was special fibrils struture in all specimens for EM. Conclusion: Diagnosis by EM is a valuable standard for renal amyioidosis. Proteinuria is established on the morphologic basis of basement membrane changes. It is highly loossible that kidney transplant and AIDS are complicated by renal amyloidosis.
出处
《中华物理医学杂志》
CAS
CSCD
1997年第4期221-222,共2页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
淀粉样变性
肾病
病理学
amyloidosis/pathol
amyloidosis/compl
kidnery disease/pathol