脑星形细胞瘤DNA倍体与ras癌基因表达的关系与预后

DNA Ploid and Ras Oncogene Expression in Astrocytomas for Prognosis

目的:探讨脑星形细胞瘤组织学结构与预后的关系。方法:应用流式细胞术和细胞免疫荧光技术,对46例脑星形细胞瘤DNA倍体和癌基因ras p21的表达进行定量分析,并结合随访进行研究。结果:肿瘤的二倍体指数(DI值)和荧光指数(FI值)以及DNA倍体出现率随组织学分级的增高而增高。ras p21阳性率和异倍体出现率分别为50%和71.74%。随组织学分级的增高p21表达亦增高。结论:脑星形细胞瘤DI>1.3和p21表达阳性者预后差。

Objective: To study the relationship between the pathological gradings of astroeytoma and the prognosis. Methods: DNA ploid and oncogene ras p21 expression in 46 cases of astrocytoma were analysed quantitatively. Results: Diploid index(DI), fluorescent index(FI) and rate of DNA aneuploid were increased with the pathological gradings. The positive rate of ras p21 expression and the frequency of aneuploid were 50% and 71.74 %. Conclusion. DI>1.3 and ras p21 positive in astrocytomas shows a worse prognosis.