锌对热应激大鼠免疫力与白细胞凋亡的影响

EFFECTS OF ZINC ON IMMUNITY AND WBC APOPTOSES IN HEAT-STRESSED RATS

为探讨高温所致免疫功能改变机制，本研究通过不同水平锌对热应激大鼠免疫学指标白细胞介素２（ＩＬ－２）和血液白细胞（ＷＢＣ）凋亡的影响进行了研究。结果表明：适当补锌可以促进脾脏淋巴细胞ＩＬ－２的生成，而低锌则使其生成减少；适当补锌可以防止血液ＷＢＣ凋亡，而低锌则可促进ＷＢＣ凋亡。结论：锌对ＷＢＣ凋亡的影响可能是高温影响机体免疫功能的重要机制之一。

In order to explore the mechanism of the change of immune function resulting from hyperthermia, interleukin2(IL2)and WBC apoptosis were tested in heatstressed rats fed different level zinc diets. The experiments revealed the following findings: 1.Adequate supplementary zinc could promote the production of IL2 in spleen lymphocyte and low zinc could reduce the production in it. 2.Adequate supplementary zinc could prevent WBC from apoptosis while low zinc could accelerate WBC apoptosis. Authors suggested that the effect of zinc on WBC apoptosis might be one of the important mechanisms of body immune function influenced by hyperthermia.