羌活提取物中异欧前胡素的药代动力学研究

Study on Pharmacokinetics of Isoimpteratorin in Dogs

目的:研究羌活提取物中异欧前胡素的药代动力学规律。方法:用HPLC-荧光检测法测定给药家犬血浆中异欧前胡素的含量,采用药代动力学软件DAS(ver2.0)处理,得到异欧前胡素的药代动力学参数。结果:家犬灌胃给药的异欧前胡素AUC0-9为1.827mg/(L.h),Cm ax为0.835mg/L,Tmax为20m in,t1/2近1.5h.结论:异欧前胡素在家犬体内的代谢过程符合一室模型,吸收、消除较快。

Objective： To Study the Pharmacokinetics of isoimpteratorin in Dogs.Methods：The concentrations of isoimpteratorin were determined by HPLC with Fluorescence Detection,pharmacokinetics parameter was calculated by DAS（ver2.0）pharmacoktnetics procedure.Results：The Pharmacokinetics parameters of isoimpteratorin after single ig in dogs are as follows： AUC 0-9 is 1.827mg/（L·h）,Cmax is 0.835mg/L,Tmax is 20min,t1/2is 1.5h.Conclusion：The absorption of isoimpteratorin in dogs is of first order kinetics.