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烟草与尿样中的代谢标记物 被引量：6

Tobacco and the metabolites in urine
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摘要 卷烟烟气进入人体后会对人体的代谢物产生影响,目前研究较多的是稠环芳烃类、烟草特有亚硝胺类和尼古丁的代谢物。文章分别介绍了稠环芳烃类代谢物1-羟基芘,烟草特有亚硝胺类代谢物NNAL和NNAL-Gluc,尼古丁的代谢物可天宁,对这些代谢物的检测方法、体内的含量水平、各种条件的影响进行了综述。 The smoke of cigarette influences the metabolites of human urine. At present, research works are focused on this metabolites of polycyclic aromatic hydrocarbons, tobacco- specific nitrosamine and nicotine. In this article, 1-Hydroxypyrene, cotinine, 4-（methylnitrosamino） -1-（3-pyridyl）-1-butanol（NNAL） and NNAL-Glucs are reviewed. The methods of determination, the concentration of metabohtes in human urine at different condition are discussed.
作者 何智慧 罗嘉 练文柳
机构地区 湖南中烟工业有限责任公司技术中心(长沙卷烟厂科研所)
出处 《化学研究与应用》 CAS CSCD 北大核心 2008年第7期805-811,共7页 Chemical Research and Application
关键词 代谢标记物 烟草特有亚硝胺代谢物(NNAL) 可天宁 1-羟基芘 metabolites 4-（methylnitrosamino）-1-（3-pyridyl）-1-butanol（NNAL） cotinine 1-hydroxypyrene
分类号 O6-1 [理学—化学]
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参考文献50

  • 1Hecht S S. Tobacco smoke carcinogens and lung cancer [J]. Cancer Inst , 1999, 91:1194-1210.
  • 2Hecht S S. Cigarette smoking and hmg cancer: chemical mechanisms and approaches to prevention [ J ]. Lancet Oncol. , 2002, 3:461-469.
  • 3Hecht S S. Tobacco carcinogens, their biomarkers, and tobacco-induced cancer[J]. Nat. Rev. Cancer, 2003, 3: 733-744.
  • 4Hecht S S. Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer [ J ]. Carcinogenesis. 2002. 23:907-922.
  • 5Stricldand P, King D. Urinary 1-hydroxypyrene and other PAH metabolitesas biomarkers of exposure to environmental PAH in air particulate matter[J ]. Toxicology Letters, 1999, 108 : 191-199.
  • 6Jacob J, Seidel A. J. Biomonitoring of polycyclic aromatic hydrocarbons in human urine [ J ]. J Chromatogr. B, 2002, 778:31 - 47.
  • 7Omland O, Sherson D, Hansen A M, et al. Urinary 1- hydroxypyrene, a PAH biomarker in foundry workers[ J ]. Cancer Detection & Prev. , 1996, 20:57-62.
  • 8Boogaard P J, van Sittert N J. Urinary. 1 -hydroxypyrene as biomarkerof exposure to polyeyclic aromatic hydrocarbons in petrochemicalindustries: baseline values and dermal uptake[J]. Biomarkers, 2000, 5:368-381.
  • 9Jongeneelen F J, Anzion R B M, Henderson P T. Determination of hydroxylated metabolites of Polycyclic Aromatic Hydrocarbons in urine [ J ] . J Chromatogr. , 1987,413:227-232.
  • 10Strickland P T, Kang D H, Bowman E D, et al. Identification of 1-hydroxypyrene glueuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry[J]. Carcinogenesis, 1994, 15:483 -487.

同被引文献73

  • 1杨军,宋硕林,Jose Castro Perez,Robert S.Plumb,许国旺.代谢组学及其应用[J].生物工程学报,2005,21(1):1-5. 被引量：51
  • 2牛静萍,胡俊平,张莉,魏士杰,牛平平,张莲娣.被动吸烟的孕妇体内生物标志物的检测与分析[J].环境与健康杂志,2005,22(2):109-110. 被引量：10
  • 3曹民,张奕伦,江朝强,林大庆,郑家强,张维森.人尿中柯铁宁含量的气相色谱-质谱测定法[J].中华劳动卫生职业病杂志,2006,24(1):39-41. 被引量：6
  • 4何智慧,罗嘉,练文柳.薄荷卷烟研究进展[J].烟草科技,2006,39(9):38-42. 被引量：25
  • 5牛红云,蔡亚岐,魏复盛,牟世芬,江桂斌.多环芳烃暴露的生物标志物——尿中羟基多环芳烃[J].化学进展,2006,18(10):1381-1390. 被引量：45
  • 6Chetiyanukornkul T, Toriba A, Kizu R, et al. Urinary 2- hydroxyfluorene and 1-hydroxypyrene levels in smokers and nonsmokers in Japan and Thailand[J]. Polycyclic Aromatic Comp, 2004, 24 (4): 467-474.
  • 7中华人民共和国环境保护部数据中心.重点城市空气质量日报(2002-2003)[EB/OL].[2009-02-16]http://data.center, mep. gov. cn/Test RunQian/air_dairy. jsp.
  • 8Strickland PT, Kang D, Bowman ED, et al. Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry [J]. Carcinogenesis, 1994, 15 (5): 483-487.
  • 9Lagorio S, Forastiere F, Lipsett M, et al. Air pollution from traffic and the risk of tumors[J]. Ann Ist Super Sanita, 2000, 36 (5): 311-329.
  • 10Raasehou Nielsen O, Reynolds P. Air pollution and childhood cancer: a review of the epideimiological literature [J]. Int J Cancer, 2006, 118 (12): 2920-2929.

引证文献6

二级引证文献14

化学研究与应用
2008年 第7期

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