摘要
To study the coordination reactions of glucosamine and α-aminoacid with copper(Ⅱ) under the physiological condition,the pH potentiometric titration was used to determine the protonation constants of glucosamine and α-aminoacid,and the formation constants of the binary and ternary complexes of glucosamine and α-aminoacid with Cu(Ⅱ) at 37℃ with ionic strength I=0.154mol/L NaCl respectively.The results indicated that all of the protonation constants of glucosamine and α-aminoacid,and stability constant of the binary and ternary complexes of glucosamine and α-aminoacid with Cu(Ⅱ) at 37℃,I=0.154mol/L NaCl are smaller than those at 25℃ with ionic strength I=0.10 mol/L KNO3 respectively.The results also indicated that the stable ternary complex could be formed from glucosamine and α-aminoacid with copper(Ⅱ).Furthermore,the two biologically active ligand,glucosamine and α-aminoacid showed higher compatible.The stability of the ternary complexes increased with the increase of protonation constant of α-aminoacid and the stability of its binary complexes.
To study the coordination reactions of glucosamine and α-aminoacid with copper（Ⅱ） under the physiological condition, the pH potentiometric titration was used to determine the protonation constants of glucosamine and α-aminoacid, and the formation constants of the binary and ternary complexes of glucosamine and α-aminoacid with Cu （Ⅱ） at 37℃ with ionic strength I = 0. 154mol/L NaCl respectively. The results indicated that all of the protonation constants of glucosamine and α-aminoacid, and stability constant of the binary and ternary complexes of glucosamine and α-aminoacid with Cu（Ⅱ） at 37℃, I =0. 154mol/L NaCl are smaller than those at 25℃ with ionic strength I = 0. 10 mol/L KNO3 respectively. The results also indicated that the stable ternary complex could be formed from glucosamine and α-aminoacid with copper（Ⅱ）. Furthermore, the two biologically active ligand, glucosamine and α-aminoacid showed higher compatible. The stability of the ternary complexes increased with the increase of protonation constant of α-aminoacid and the stability of its binary complexes.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2008年第7期883-886,共4页
Chemical Research and Application
基金
河南省教育厅资助项目(No2000150018)
