2型糖尿病并发骨质疏松症相关因素临床评价

Clinical Analysis of Patients with Type 2 Diabetes Complicated with Osteoporosis and Correlative Factor

目的研究2型糖尿病(2DM)患者并发骨质疏松(OP)的特点,以期减少2DM患者的并发症。方法采用双能X线骨密度仪测量56例(病例组)2DM患者腰椎(L1-L4)和左侧髋部(股骨颈、大转子、Ward′S三角区)的骨密度(Bone Mineral Density,BMD),并以相同年龄、性别的正常人(60例)对照,比较在不同病程、有无视网膜病变和微量蛋白尿患者在56例中的OP发生率。结果病例组:腰椎骨BMD值达OP诊断标准者34例(60.71%),左侧髋部BMD值达OP诊断标准者29例(51.79),对照组分别是4例(6.67%)和3例(5.00%),两组比较有显著性差异(P<0.01);2DM病程≥10年35例,BMD值达OP诊断标准者29例(85.29%),病程<10年21例,BMD达OP诊断标准者5例(23.81%),两组比较有显著性差异(P<0.01);有视网膜病变35例,BMD值达OP诊断标准者30例(87.14%),无视网膜病21例,BMD值OP者4例(19.05%),两组比较有显著性差异(P<0.01);有蛋白尿32例,BMD值达OP诊断标准者28例(87.50%),无蛋白尿24例,BMD值达OP者3例(12.50%),两组比较有显著性差异(P<0.01)。结论2DM患者出现BMD值达OP诊断标准的检出率显著高于正常组;2DM患者并发OP与病程长短、有无视网膜病变和蛋白尿等因素密切相关。

Objective Osteoporosis is a progressive bone diseaes with a high incidence.The pathogenesis of osteoporosis is still unknown.Study the Patients with type 2 diabetes complicated with Osteoporosis.and Correlative Factro It is complicating disease at decrease and synergy of therapeutic efficacy.Methods this paper： The BMD ofproximal femur（neck,Troch and ward＇s triangle）and orthopic lumbar vertebrae（L1-4） by dual energy Xray absorptiometry of 56 type 2 diabetic patients（diabetic group）were measured.and were compared to normal subjects（control group）with the sable age.sexan dliving area.Analysis of body height and weight and sex and Patients with retintis and urinay protein.Results The case gyoup of BMD T-sed≤-2.5SD 34（60.71%）.The comparisom group（60） T-sed≤-2.5SD.4（6.67%（P〈0.01））.The course of disease 2DM≥10year OP29（82.86%）,Retntis35 with OP30（85.29%）;Urinayprotein 32 with OP28（87.50%）.The values of BMD inthediabetic grou were obviously lower than those in the control group（P〈0.01）.Conclusions Osteoporosis is a progressive bone diseaes with a high incidence.The pathogenesis of osteoporosis is still unknown,so,it is necessary to study the pathogienic mechanisms of osteoporosis of bone mineral density（BMD） at extensively and deeply.The BMD loss is coannon in type 2 diabetic patients.And is closely related to the disease coures,retinopathy and albuminuria.