胃肠道间质瘤CD117 CD34和Ki-67的表达与临床病理因素的相关性

Expression of CD117 CD34 and Ki-67 in Gastrointestinal Stromal Tumors and its Correlation with Clinicopathological Factors of GISTs

目的:探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)CD117、CD34和Ki-67的表达率和表达强度及其与临床病理相关因素和危险度的关系。方法:应用免疫组化S-P法检测57例GISTs的CD117、CD34和Ki-67的表达情况,并分析上述免疫组化指标在表达率方面与临床病理相关因素(性别、年龄、发生部位)的关系。并对这些病例进行危险度分级,进一步探讨上述免疫组化指标在表达程度方面与危险度之间的关系。结果:CD117和CD34的阳性表达率分别为84.2%、71.9%。CD34阳性表达率在不同性别、年龄组之间没有显著性差异,但在肠道外GISTs阳性表达率高于肠道(P<0.05)。CD117的阳性表达强度和Ki-67增殖指数在不同的危险度之间存在显著性差异(P<0.05)。且CD117阳性表达强度、Ki-67增殖指数和危险度的分级呈正相关。结论:CD117和CD34在GIST中均呈高表达率,但肠道GIST诊断时,CD117的阳性表达更准确、可靠。CD117表达强度和Ki-67增殖指数和危险度的分级呈正相关,可能是判断GIST危险度的可靠指标之一。

Objective：To investigate the expression rates and the expression levels of CD117、CD34 and Ki-67 in gastrointestinal stromal tumors（GISTs）and its relationship with the clinicopathological features and risk rank of G1STs.Methods：To detect the expression rates and the expression levels of CD117、CD34 and Ki-67 in 57 cases of GISTs by immunohistochemical S-P,and to analysis the relations of immunohistochemistry of the above indicators and related clinicopathological factors（gender,age,location）.To further explore the relationship of the rank of risk and immunohistochemistry of the above indicators.Results：The positive expression rates of CD117 and CD34 were 84.2% and 71.9%.There had no significant difference in the different gender and age group on the positive expression rates of CD34.The positive expression rates of CD34 in parenteral is higher than that of intestinal.The positive Expression intensity of CD117 and the proliferation index of Ki-67 is significant different in the different rank of risk（P〈0.05）.The positive expression intensity of CD117 and the proliferation index of Ki-67 was positively correlated with risk classification.Conclusion：CD117 and CD34 in GIST was in high expression levels,and had a certain significance in the diagnosis of GIST.And the expression intensity of CD117 and the proliferation index of Ki-67 was positively correlated with risk classification.They may be one of the.reliable indicators in judging the risk of GIST.