冠心一号方对冠心病患者的治疗作用及对同型半胱氨酸的影响

Therapeutic Effect of Guanxin Prescription No.1 for Coronary Heart Disease and Its Influence on Homocysteine

【目的】观察具有益气养阴、活血祛瘀作用的冠心一号方对冠心病患者的治疗作用及对同型半胱氨酸(Hcy)的影响。【方法】将60例冠心病患者随机分为治疗组和对照组各30例。两组均给予常规西药基础治疗,治疗组在基础治疗上加服冠心一号方(由党参、麦冬、五味子、玉竹、川芎、知母、丹参、三七、郁金等组成)。两组均以4周为1个疗程。主要观察治疗后患者临床症状总疗效及心绞痛、心电图疗效,并观察血脂、血清Hcy及颈动脉内膜—中层厚度(IMT)等相关指标改善情况。【结果】治疗组治疗后临床症状总疗效及心绞痛、心电图疗效均优于对照组(P<0.05或P<0.01)。治疗组治疗后血中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)含量均有下降(P<0.05),而对照组的下降作用不明显(P>0.05)。治疗后治疗组Hcy水平较治疗前显著下降(P<0.05),对照组Hcy水平较治疗前也有所下降,但差异无显著性意义(P>0.05);两组治疗后比较,治疗组Hcy水平下降幅度优于对照组(P<0.05)。【结论】冠心一号方治疗冠心病的疗效优于对照组,而且具有降低冠心病患者同型半胱氨酸的作用。

Objective To observe the therapeutic effect of Guanxin Prescription No. 1 （ GP1 ） for coronary heart disease （CHD） and its influence on homocysteine （Hcy）. Methods Sixty CHD patients were equally randomized into two groups. Both of the two groups received routine western medicine, and the treatment group additionally received GP1 （mainly composed of Radix Codonopsis, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Rhizoma Polygonati Odorati, Rhizoma Chuanxiong, Rhizoma Anemarrhenae, Radix Salviae Mihiorrhizae, Radix Notoginseng, Radix Curcumae, etc ）. Four weeks constituted one treatment course. The total therapeutic effect and the effect on angina pectoris （AP） and electrocardiogram （ECG） were evaluated after treatment. Meanwhile, the changes of blood lipid levels, serum Hcy and internal-middle thickness （IMT） of carotid artery were observed. Results The total therapeutic effect and the effect on AP and ECG in the treatment group were superior to those in the control group （P 〈0. 05 or P 〈0.01 ）. Blood levels of total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） and Hcy were decreased in the treatment group after treatment （P 〈 0. 05 compared with those before treatment）. No significant difference of the above indexes was found in the control group after treatment （P 〉 0.05 compared with those before treatment）. The decrease of serum Hcy level was obvious in the treatment group than that in the control group （ P 〈 0. 05 ）. Conclusion Guanxin Prescription No. 1 exerts a certain effect for coronary heart disease, and can decrease the serum level of Hcy.