中药配合黄芪离子导入治疗单纯疱疹病毒性角膜炎的疗效观察

Therapeutic Effect of Chinese Medicine Combined with Ion-introduction of Radix Astragali Injection for Herpes Simplex Keratitis

【目的】观察中药配合电离子导入治疗单纯疱疹病毒性角膜炎的疗效。【方法】将单纯疱疹病毒性角膜炎患者90例(104眼)随机分为两组,治疗组45例(53眼)用抗病毒药物治疗,内服中药(以决明子、蔓荆子、蝉蜕、钩藤、山栀子、连翘、菊花、川芎等为基本方,随证加减),同时应用黄芪注射液电离子导入治疗。对照组45例(51眼)单纯用抗病毒药物治疗。观察两组治疗前后视力和临床症状的变化,并随访观察2年。【结果】治疗组治愈19眼,好转27眼,无效7眼,总有效率为86.79%;对照组治愈10眼,好转21眼,无效20眼,总有效率为60.78%。两组比较,治疗组的疗效明显优于对照组(P<0.01)。两组视力情况,治疗后两组的视力均较治疗前有明显改善(P<0.01),且治疗组的改善作用优于对照组(P<0.05)。经2年随访,治疗组复发3眼,对照组复发6眼,两组复发情况比较,差异有统计学意义(P<0.01)。【结论】中药配合眼部电离子导入是治疗单纯疱疹病毒性角膜炎的一种有效方法。

Objective To observe the therapeutic effect of Chinese medicine combined with ion-introduction of Radix Astragali Injection （RAI） for herpes simplex keratitis （HSK）. Methods Ninety HSK patients （104 affected eyes） were randomized into two groups. Both of the two groups received anti-virus drugs, and the treatment group （45 patients with 53 affected eyes） received oral use of decoction of Chinese medicines （mainly composed of Semen Cassiae, Fructus Viticis, Periostracum Cidadae, Ramulus Uncariae cum Uncis, Fructus Gardeniae, Fructus Forsythiae, Flos Chrysanthemi, Rhizoma Chuanxiong, etc. ）, and ion-introduction of RAI. The changes of vision and clinical symptoms before and after treatment were observed, and a 2-year follow-up was carried out. Results In the treatment group, 19 eyes were cured, 27 effective, 7 ineffective, and the total therapeutic effective rate being 86. 79% ; in the control group, 10 eyes were cured, 21 effective, 20 ineffective, and the total therapeutic effective rate being 60.78%. The therapeutic effect in the treatment group was superior to that in the control group （ P 〈 0.01 ） The vision in the two groups was improved after treatment （ P 〈 0.01 compared with those before treatment）, and the improvement of vision in the treatment group was superior to that in the control group （P 〈 0.05 ）. The result of the follow-up showed that recurrence Occurred in 3 eyes of the treatment group, and in 6 eyes of the control group, the difference being significant （P 〈0. 01 ）. Conclusion Chinese medicine combined with ion-introduction of Radix Astragali Injection is effective for herpes simplex keratitis.