川芎嗪辅助癫痫药物治疗外伤性癫痫28例疗效观察

Effect of Tetramethylpyrazine Assisting Antiepileptic Drugs for Traumatic Epilepsy:An Observation of 28 Cases

【目的】观察川芎嗪辅助癫痫药物治疗外伤性癫痫的疗效。【方法】将56例外伤性癫痫患者随机分为两组,对照组28例患者给予常规抗癫痫药物治疗,治疗组28例在常规抗癫痫药物治疗的基础上,应用川芎嗪针静脉滴注,1个月为1个疗程,连续5个疗程后停用,原抗癫痫药物继续应用。两组均观察及随访1年后评价疗效。【结果】治疗组治愈12例,好转13例,未愈3例,总有效率为89.29%;对照组治愈4例,好转17例,未愈7例,总有效率为75.00%。两组比较,治疗组疗效优于对照组(P<0.05)。【结论】在常规抗癫痫药物治疗的基础上,川芎嗪的应用可显著提高外伤性癫痫的治疗效果。

Objective To observe the therapeutic effect of tetramethylpyrazine （TM） assisting antiepileptic drugs for traumatic epilepsy. Methods Fifty-six traumatic epilepsy patients were equally randomized into two groups： the control group received routine antiepileptic drugs and the treatment group received routine antiepileptic drugs combined with intravenous injection of TM. One month constituted one treatment course. After 5 treatment courses, TM was suspended but the medication of antiepileptic drugs was still on. A one-year follow-up was carried out and the therapeutic effect was evaluated in the two groups. Results In the treatment group, 12 patients were cured, 13 effective and 3 ineffective, and the total effective rate being 89.29%; in the control group, 4 patients were cured, 17 effective and 7 ineffective, and the total effective rate being 75.00% . The therapeutic effect in the treatment group was superior to that in the control group （P 〈 0.05 ）. Conclusion The application of TM has a synergistic action on the routine antiepileptic drugs for traumatic epilepsy.