新生儿血清胆红素与肌酸激酶同工酶的关系

Relationship between Bilirubin and Serum CK-MB

目的观察新生儿血清胆红素与肌酸激酶同工酶(CK-MB)的关系,探讨新生儿血清胆红素与心肌损害的关系。方法对40例正常新生儿、40例生理性黄疸新生儿、40例病理性黄疸新生儿的CK-MB水平进行测定并比较。结果正常组新生儿的CK-MB水平与生理性黄疸组、病理性黄疸组的比较差异均有统计学意义(P<0.01),生理性黄疸组与病理性黄疸组间差异亦有统计学意义(P<0.01)。结论高胆红素可引起心肌损害,血清CK-MB可作为胆红素对心肌细胞损伤的一个重要生化指标。

Objective To measure the changes of serum CK - MBs concentration in neonates suffering from pathologic jaundice. Methods Forty neonates with pathologic jaundice, 40 with physiologic jaundice and 40 normal were enrolled to detect bilirubin and serum CK - MB concentration. Results There was significant difference in serum CK - MBs concentration between 3 groups （ P 〈0. 01 ）. The CK- MB concentration of pathologic jaundice group was significantly higher than that of the other two （ P 〈 0. 01 ）. Conclusion High bilirubin can cause myocardial damage. Serum CK - MB can be used as a key biochemical indicators of myocardial injury due to bilirubin.