新生儿血渗透压测定的临床意义

Clinical research on blood osmotic pressure of newborns

目的探讨患病新生儿血渗透压改变及其对疾病转归的影响。方法随机选取96例患病新生儿,其中新生儿肺炎36例,新生儿黄疸21例,新生儿窒息24例,新生儿寒冷损伤综合征24例,于入院时采集静脉血检查电解质、血糖、肾功,公式法计算血渗透压,以20例正常新生儿血渗透压作为对照。根据血渗透压制定输液方案。结果新生儿肺炎患儿血渗透压(261.0±1.5)mO sm/L,新生儿黄疸患儿血渗透压(270.5±2.0)mO sm/L,新生儿窒息患儿血渗透压(252.2±3.8)mO sm/L,新生儿寒冷损伤综合征患儿血渗透压(258.0±3.2)mO sm/L,与正常新生儿血渗透压(288.6±17.5)mO sm/L比较,差异均有显著性(P<0.05)。经过调整输液方案,96例患儿均痊愈出院。结论患病新生儿血渗透压较正常新生儿低,治疗时宜适当补钠,血渗透压测定对患儿病情判断及指导治疗可提供帮助。

Objective To explore effects of blood osmotic pressure in neonatal diseases. Methods 96 hospitalized newborns were randomly selected for detecting blood osmotic pressure. There were 36 newborns with neonatal pheumonia, 21 newborns with neonatal iaundice, 24 newborns with asphyxia of newborn, and 15 newborns with neonatal cold injure syndrome. 20 normal newborns were detected blood osmotic pressure as control. Result Blood osmotic pressure of newborns with neonatal pheumonla, neonatal iaundice, asphyxia, cold injure syndrome, and control were 261.0±1. 5 mOsm/L, 270.5±2.0 mOsm/L,252.2±3.8 mOsm/L, 258.0±3.2 mOsm/L,and 288.6±17.5 mOsm/L, respetively. The blood osmotic pressure of newborns with diseases was significant difference from that of control （P〈0.05）. Conclusion Blood osmotic pressure of newborn with diseases is lower than that of normal newborns, which suggests that blood osmotic pressure can show the pathogenetic condition.