间质性膀胱炎36例治疗探讨

Discussion of therapy for interstitial Cystitis

目的探讨及评价治疗间质性膀胱炎(IC)的方法。方法将36例IC患者随机分为膀胱水囊扩张加透明质酸钠灌注组(A组)和膀胱水囊扩张加口服丙咪嗪组(B组)各18例规范治疗3个月,观察两组在开始治疗后3、6个月时的疗效并进行比较。结果开始治疗后3个月时,A、B两组ICSI、ICPI评分与治疗前相比,差异均有显著性(P<0.01);组间比较,差异无显著性(P>0.05);治疗后6个月时,A、B两组ICSI、ICPI评分及膀胱容量与治疗前相比,差异均有显著性(P<0.01),同时A、B两组间比较,差异亦有显著性(P<0.01)。结论两种方法均为治疗IC的有效方法,但水囊扩张加透明质酸钠灌注的疗效程度和持续时间更佳。

Objective To discuss and evaluate the therapy of interstitial Cystitis （IC）. Method 36 cases with IC were randomly divided into 2 groups, including Group A and Group B. Group A was treated with bladder dilation by water sac and intravesical instillation with sodium hyaluronate. Group B was treated with bladder dilation by water sac and imipramine. Both groups accepted standard treatment for 3 month. The curative effect was observed, Result ICSI and ICPI of both groups 3 months and 6 months after treatment demonstrated preponderance compared to that before treatment （P^O, 01）. There was no significant difference of ICSI and ICPI 3 months after treatment between the 2 groups （P^0. 05）, whereas ICSI and ICPI 6 months after treatment revealed significant difference in the two groups, Conclusion Both therapies are effective for IC. Bladder dilation by water sac and intravesical instillation with sodium hyaluronate might be better than the other one.