c—myc、c—fos及PCNA在胸腺瘤中的表达及意义

The significance of c-myc, c-fos and proliferating cell nudear angigen （PCNA） expression in thymoma

目的探讨c-myc、c-fos和人类增殖细胞膜抗原（proliferating cell nuclear antigen，PCNA）在胸腺瘤中的表达及其与胸腺瘤组织分型和临床分期的关系。方法应用免疫组织化学S-P法研究c—myc、c-fos和PCNA在41例胸腺瘤和18例非瘤胸腺组织中的表达。结果c—myc、c—fos和PCNA在胸腺瘤中的阳性率分别为63．4％、34．1％和90.2％。c—myc、c—fos和PCNA在胸腺瘤中的表达与非肿瘤胸腺组织中的表达差异有统计学意义（P〈0．05）。c—myc和PCNA的表达与胸腺瘤的组织分型与临床分期相关（P〈0．05）。c—fos的表达与胸腺瘤的组织分型与临床分期没有明显相关性（P〉0．05）。结论c—myc、c-fos和PCNA可能在胸腺瘤的发生和发展中起重要作用。c—myc和PCNA的表达可以作为胸腺瘤病理诊断的重要参考指标。

Objective To correlate the expression of c-myc, c-fos and PCNA expression in the thymoma with histological type and clinical stage. Methods C-myc, c-fos and PCNA expression in paraflin-embedded sections of 41 thymomas and 18 non-neoplastic thymus （NNT） were detected by immunohistochemical S-P assay. Results The positive rate of c-myc, c-fos and PCNA were 63.4% （27/41）, 34.1% （14/41） and 90.2 % （37/41）. The expression of c-myc, c-fos and PCNA in NNT was different with the expression in thymoma （ P 〈 0.05）. The expression of c-myc and PCNA correlated with histological type and clinical stage of thymoma （ P 〈 0.05）. No correlation was found between c-fos expression and different histological type or different clinical stage of thymoma. Conclusion c-myc and PCNA may play an importantrole in the occurrence and development of thymoma. The expression of c-myc and PCNA in thymoma may serve as an important consultative index in pathological diagnosis.