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移植大鼠心脏局部CD134表达与急性排斥反应的相关性研究 被引量:1

The relationship between acute rejection and infiltration of CD134^+ lymphocytes in heart allografts
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摘要 目的探讨大鼠浸润淋巴细胞CD134表达与移植心脏生存时间的关系。方法建立大鼠异位心脏移植模型,术中静脉应用CD45单克隆抗体(CD45mAb)及供体脾细胞。术后切取移植心脏,检测局部浸润细胞CD134表达情况。结果在正常大鼠心脏,CD134阳性细胞很少;在CD45mAb及联合应用供体脾细胞组,CD134阳性细胞较单用脾细胞组和不用药组均明显减少。结论排斥反应与浸润淋巴细胞的CD134表达呈正相关。 Objective To analyze the relationship between survival of aUografts and CD134 expression of infiltrating eeUs. Methods A simplified heterotopie rat heart transplantation model was established, and CD45mAb (1 mg/kg) was intravenously injected or associated with donor splenoeytes ( 1 × 10^9 eells/100 g). The transplanted heart harvested and the expression of CD134 in infiltrating cells was performed. Results In normal rat heart, few CD134 ^+ cells could be found. The allografts in CD45mAb or associated donor splenoeyte groups had significantly lower CD134^ + expression than those treated with splenoeytes and no therapy groups. Conclusion These findings suggest that rejection is positively correlated with CD134^ + cells .
出处 《临床和实验医学杂志》 2008年第7期17-18,共2页 Journal of Clinical and Experimental Medicine
关键词 CD45单克隆抗体 心脏移植 CD134 CD45mAb Heart transplantation CD134
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