摘要
目的观察甘露醇反复长期使用后颅内压(ICP)的变化规律,以探讨甘露醇的有效使用方法。方法选择25例重型颅脑损伤患者术后ICP〈30mmHg的患者作为研究对象,予甘露醇静脉滴注,1.0g/(kg·次)/次,每4—6h1次,连续使用7d以上。同时应用颅内压监测仪持续监测ICP,并进行分析比较。结果用药后ICP均明显下降,至第7d仍能保持有效降颅压;但第2d开始治疗后ICP最低值高于第1d、ICP最大降幅百分比小于第1d,差异有显著性(P〈0.05)。结论连续使用甘露醇后降颅内高压的效力于第2d开始减弱,但至第7d仍能保持有效的降颅压。
Objective To investigate the changes of intracranial pressure(ICP) after long - term repeated use of mannitol,and explore the effective use of mannitol. Methods 25 patients experiencing operations after severe craniocerebral injury received intravenous 20% mannital( 1g/ kg), once in 4 - 6 hours, and given continuously monitoring of ICP for 7 days, when ICP was below 30 mmHg. Results ICP could be decreased significantly after the use of mannitol for 7 days,but the nadir of ICP after treatment in 2 -7 days were higher than those in the first day,and the maximum decrease percent of ICP were less than those in the first day( P 〈 0.05 ). Conclusion The descending effectiveness of ICP is active for 7 days after the repeated use of mannitol,but it begin to weaken from the second day.
出处
《临床和实验医学杂志》
2008年第7期23-24,共2页
Journal of Clinical and Experimental Medicine
关键词
甘露醇
颅内压
重型颅脑损伤
Mannitol
Intraeranial pressure
Severe craniocerebral injury