Tei指数评价^(131)I治疗甲状腺功能亢进性心脏病心功能变化

Tei index rating cardiac function of thyrotoxic cardiopathy after 131I treatment

目的通过Tei指数评价同位素131I治疗甲状腺功能亢进性心脏病的心脏整体功能,观测其治疗后的改善程度,指导临床调整用药。方法对56例甲状腺功能亢进性心脏病患者治疗前行超声心动图检查,同位素131I治疗3月、6月、1年后分别行超声心动图检查,多普勒法测定Tei指数及其它心脏功能指标的变化。结果甲状腺功能亢进性心脏病患者的心脏整体功能Tei指数治疗前后有明显的变化,治疗前Tei指数均明显增高为(0.76±0.13),治疗后Tei指数均不同程度的降低,一年后Tei指数降至(0.42±0.14),并随着甲状腺功能亢进性心脏病临床症状的治愈与好转,Tei指数也随着相应降低。结论由于Tei指数测量方法简便、重复性强,并不受心率、心脏几何形态、心室收缩压和舒张压的影响,且其更能反映心脏的整体功能,通过Tei指数值的高低判断心脏受累程度,并通过同位素131I治疗前后的心脏Tei指数变化能全面的评价治疗后心脏功能的改善程度,并可适时的调整用药。

Objective ^131I treatment of cardiac function in patients with thyrotoxic cardiopathy was evaluated by Tel index rating. Observation on improvement after treatment was carried out for adjusting clinical application of ^131I. Methods 56 cases of thyrotoxic cardiopathy were examined by echocardiography before treatment, and three months, six months and one year after^131I treatment. Tel index and other indexes of heart function were determined. Results Cardiac function in cases of thyrotoxic cardiopathy and Tel index had been obviously changed after ^131I treat- ment. Tel index increased significantly before treatment, and it was decreased in varying degree after ^131I treatment. The lowering of Tei index was corresponding with the improvement of clinical symptoms. Condusion Measuring method of Tel index is simple and free from the influence of heart rate, cardiac geometrical figure and systolic and diastolic pressure of heart. Tei index can be applied for evaluation of the improvement of car- diac function after ^131I treatment and timely adjustment of medication may be carried out.