环丙沙星离子选择性电极的制备及应用

Preparation and Application of Ion-selective Electrode of Ciprofloxacin

目的:制备一种以环丙沙星与四苯硼钠缔合物为活性物的PVC膜环丙沙星选择性电极。方法:用此电极以标准曲线法对盐酸环丙沙星及其两种制剂进行含量测定。结果:电极的响应范围10^(-1)～10^(-5)mol·L^(-1),斜率为37.4 mV/pC,平均回收率为97.7%,RSD=2.4%(n=8)。结论:方法灵敏度高,操作简便,结果与HPLC法相符。

Objective： To preparation A PVC membrane eiprofloxaein （CFLX） selective electrode based on CFLX and sodium tetraehenylborin molecular association complex. Method： The electrode was used for the determination of CFLX and its preparations by standard curve method. ResuLt： The electrode exhibited response for CFLX with a slope of 37. 4 mV/pC over the concentration range of 10 ^-1 - 10^-5mol . L^-1. The average recovery was 98.1% with a RSD of 2.4% （ n = 8）. ConcLusion： The method has good sensitivity,and the procedures of this method are simple. The results obtained agreed with those by HPLC method.