猪无名高热综合征临床病例研究

A Clinical Study on the Swine High Fever Syndrome

通过电镜直接观察从吉林省、辽宁省部分地区收集到的猪无名高热综合征病料,发现主要为猪繁殖与呼吸综合征病毒、副粘病毒、猪瘟病毒;将从吉林省的无名高热综合征病料中分离到的副粘病毒、病料原液以及由病料制得的自家灭活疫苗分别接种到血清检测无名高热综合征主要病原抗体阴性的健康仔猪,同时设立阴性对照,对临床感染的仔猪进行了病理变化、病毒分离、细菌检测等方面的鉴定分析,对无名高热综合征病原的致病特点、发病规律和灭活疫苗使用中出现的抗体依赖性增强作用(ADE)进行了探讨研究。结果表明:初步认定两省部分地区无名高热综合征的主要病原体为PRRSV,由病料所制得灭活疫苗在活体中具有抗体依赖性增强现象。

Materials about incidence of swine high fever syndrome were gained by epidemiological investigation of parts of Jinlin and Liaoning province.Porcine reproductive and respiratory syndrome virus,paramyxovirus virus and swine fever virus were mainly detected by electron microscope;Serum testing swine high fever syndrome major pathogen antibody negative health piglets inoculated with paramyxovirus virus,virus solution,inactivated vaccine isolated from tissue samples in Jinlin province,meanwhile a negative control was made.Detection methods were used to study the clinical infection piglets including pathological testing,virus isolation,bacterial Detection.Pathogenic characteristics,morbidity regularity of swine high fever syndrome have been discussed as well as antibody dependent enhancement（ADE） which was taken place in the employment of inactivated vaccine.The results showed that： PRRSV was the major pathogen of swine high fever syndrome in the two provinces preliminarily and antibody dependent enhancement（ADE） phenomenon was concomitanted in the apply of inactivated vaccine.