抗龋IgY牙膏对乳牙防龋效果的临床研究

Clinical study of anticarious IgY tooth paste in deciduous teeth caries prevention

目的：研究含抗变形链球菌鸡蛋黄免疫球蛋白抗体IgY的牙膏对乳牙的防龋效果。方法：采用双盲法，以260名3～4岁幼儿为对象。随机分为实验组和对照组，每位受试者均经过3个月洗脱期，洗脱期内统一使用不含IgY的空白牙膏，洗脱期后，实验组应用抗龋IgY牙膏，对照组应用不含IgY的空白牙膏，并分别在实验前、实验后6个月、1年、1．5年进行口腔检查。结果：本研究3～4岁幼儿的患龋率为53．78％，在基线检查中，实验组与对照组间的患龋率、龋均和龋面均均无显著性差异；应用抗龋IgY牙膏6个月后，两组间发病率、新增龋均、新增龋面均均无显著性差异（P〉0．05）；1年后，实验组与对照组间新增龋均、新增龋面均有显著性差异（P〈0．05）；18个月后实验组与对照组间的发病率、新增龋均和新增龋面均有显著性或极为显著性差异（P〈0．01），实验组明显低于对照组。结论：抗龋IgY牙膏的应用能降低乳牙龋病的发病率及新增龋均、龋面均，具有一定的防龋效果，有较好的应用前景。

AIM： To study the effect of IgY tooth paste containing egg yolk antibody to Streptococcus mutans in the prevention of deciduous teeth caries. METHODS ： A double - blind study was used. 260 chidren of aged 3 - 4 years from three preschools in the Zhabei district of Shanghai were involved, After a 3 - month elution period, their caries states were examined as baseline. Then they were divided into 2 groups randomly（ test group and control group）. Every subject brushed with IgY tooth paste or control paste respectively. Prevalence rate ,dmft,dmfs were examined on baseline,after 6 months , 12 months and 18 months. RESULTS： The prevalence of each childhood caries was 53.78%. At baseline, the caries states showed no difference between the test group and control, but carious incidence and the change of draft ,dmfs showed significant difference between the two groups both after IgY tooth paste used 12 months and 18 months. CONCLUSION： The application of the anticarious IgY tooth paste can reduce the carious incidence,draft and dmfs, and it is efficient in preventing caries on deciduous teeth, so it may be used as a suitable methods to prevent the deplal caries in children.