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抗艾滋病药奈韦拉平合成技术研究新进展 被引量：6

Progress in synthesis of the anti-AIDS drug nevirapine
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摘要 奈韦拉平(NVP)是目前使用最广泛的抗艾滋病药物之一,其合成方法的研究近年来受到广泛关注。笔者介绍了目前国内外该化合物合成技术的最新进展,分析了6条合成路线,讨论了各合成方法的优缺点,并对其合成技术的发展作了展望。 Nevirapine （NVP） is a widely used anti-AIDS drug, and has now been attracting great attention. This paper reviewed the latest progress in the synthesis methods of NVP. Six synthetic routes were analyzed,and both the merits and limitations of the synthetic methods were discussed. The prospect and future development trend of NVP synthetic technology were proposed as well.
作者 许青青 杨亦文
机构地区 浙江工业大学浙西分校化学与制药工程系 浙江大学制药工程研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2008年第13期1089-1092,共4页 Chinese Journal of New Drugs
基金 浙江省衢州市科技局资助项目(20051037)
关键词 奈韦拉平 抗艾滋病药物 合成 nevirapine anti-AIDS drug synthesis
分类号 R978.7 [医药卫生—药品] R916.42 [医药卫生—药学]
  • 相关文献

参考文献10

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二级参考文献26

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共引文献9

同被引文献20

  • 1孟庆伟,曾伟,赖琼,李悦青,赵伟杰.奈韦拉平的合成[J].中国医药工业杂志,2006,37(1):5-7. 被引量：12
  • 2Schneider H,Christmann A. Process for the preparation of nevirapine ( 11 -- eyelopropyl - 5,11 - dihydro - 4 -- methyl -- 6 H -- dipyrido[3, 2 -- b: 2' 3' -- e] [1,4 -- diazepin] -- 6 -- one). DE: 4403311,1995--04 --20.
  • 3Hargrave K, Proudfoot J. 5,11 -- dihydro-- 6H -- dipyrido( 3,2 -- B,2'3'--E) (1,4)diazepines and their use in the prevention or treatment of HIV infection. US: 5366972,1994-- 11 -- 22.
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  • 7Gharpure M,Bhawal B. An improved process for indusrrial manufaclure of nevirapine. WO: 2007010352,2007--01 -- 25.
  • 8GHARPURE M, BHAWAL B, GOVENKAR M, et al. An improved process for industrial manufacture of nevirapine. WO: 2007010352,2007 -01- 25.
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引证文献6

二级引证文献7

中国新药杂志
2008年 第13期

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