摘要
目的探讨VEGF-C与VEGFR-3在胃癌组织中的表达情况及其与胃癌临床病理特征的关系。方法以7例正常胃黏膜为对照,采用免疫组化检测38例胃癌组织中VEGF-C与VEGFR-3的表达情况,并分析其与胃癌临床病理特征之间的关系。结果38例胃癌组织中VEGF-C阳性率为63.2%(24/38),而VEGFR-3阳性率为71.1%(27/38),两者的阳性率均高于正常黏膜组织,差异均有显著性(P<0.05);二者在有淋巴结转移组的表达强度均高于无转移组(P<0.05),而与肿瘤的浸润、分化程度之间无明显差异(P>0.05);二者之间有相关性(P<0.01)。结论胃癌组织中存在VEGF-C与VEGFR-3的高表达,且均与淋巴结转移有关。
Objective To study the relationship between the expression of vascular endothelial growth factor-c（VEGF-C） and its receptor VEGFR-3 with the clinical and pathological characteristics of gastric carcinoma. Methods 38 gastric carcinoma specimens were identified with immunohistochemistry by antibodies against VEGF-C and VEGFR-3 respectively, and the relationship between their expression and the clinical, pathological characteristics were analyzed. Results In 38 gastric cancer specimens,the VEGF-C and VEGFR-3 proteins were positively expressed in 63.2% and 71. 1% respectively; both higher than the normal specimens （ P 〈 0. 05 ） ;and they were both correlated with lymphatic metastasis significantly（ P 〉 0. 05 ）. The expression of VEGF-C and VEGFR-3 had a positive correlation（ P 〈 0. 01 ）. Conclusion VEGF-C and VEGFR-3 express higher in gastric cancer tissues and are both correlated with lymphatic metastasis, which might result in a higher risk for lymph node metastasis.
出处
《临床消化病杂志》
2008年第3期150-152,共3页
Chinese Journal of Clinical Gastroenterology
