龙血竭中龙血素A与龙血素B在大鼠体内的组织分布研究

Study on tissue distribution of loureirin A and loureirin B of resina draconis in rats

目的研究龙血竭中龙血素A、龙血素B在大鼠体内的组织分布情况。方法按100 g大鼠给予龙血竭250 mg,灌胃给药,用HPLC法测定不同时间点的组织浓度。结果龙血素A、B在肝脏及肾脏浓度最高,然后依次是肺、脾、心、脑。结论龙血素A、B在大鼠体内主要分布于血流量大的脏器。

Objective To study the tissue distribution of loureirin A and loureirin B in rats. Methods After intragastric （i. g. ） administration of loureirin A and loureirin B at doses of 250 mg/100 g in rats, the tissue concentrations at different time points were determined by HPLC. Results After i. g. administration, the main tissue distributions of loureirin A and loureirin B in rats were similar. The loureirin A and loureirin B concentrations in the liver and kidney were the highest and those in the spleen, heart, lung, brain, and muscle decreased sequentially. Conclusion There was an extensive distribution of loureirin A and loureirin B in rats.