2型糖尿病患者非糖尿病一级亲属血清高敏C反应蛋白与胰岛素抵抗的相关性

Relation of high-sensitivity C-reactive protein with insulin resistance in the first-degree relatives of type 2 diabetics

目的探讨血清高敏C反应蛋白(hsC-RP)在2型糖尿病(T2DM)发病中的作用。方法利用ELISA方法检测72例T2DM患者非糖尿病一级亲属(FDR)和68例健康对照者(NC)血清hsC-RP、FIns、FPG等,并用HOMA-IR公式计算胰岛素抵抗指数。结果(1)FDR组血清hsC-RP水平较NC组升高(P<0.01),HOMA-IR高于NC组(P<0.01);(2)血清hsC-RP水平与HOMA-IR(r=0.307,P<0.01)、FIns(r=0.286,P<0.05)、BMI(r=0.250,P<0.05)、LDL-C(r=0.302,P<0.05)、TC(r=0.267,P<0.05)相关。结论慢性炎症与胰岛素抵抗密切相关,hsC-RP升高是2型糖尿病发生的一个预测因子。

Objective To explore the possible pathogenesis of type 2 diabetes. Methods Serum samples were collected from 72 first-degree relatives of type 2 diabetic subjects and 68 normal subjects. Results Circulation levels of high-sensitivity C-reactive protein （hsCRP） and insulin resistance index estimated by homeostasis model assessment （HOMA-IR） were significantly higher in first-degree relatives than in controls （P 〈 0.01）. Circulation levels of hsCRP was correlated to HOMA-IR （r = 0. 307, P 0.01） ,fasting insulin （Fins） （r=0. 286,P〈0. 05）, body mass index （BMI） （r=0. 250, P〈0.05） ,low-density lipoprotein cholesterol （LDL-C） （r=0. 302, P〈0.05） and total cholesterol（TC） （r=0. 267, P〈 0.05）. Conclusions The data support the hypothesis that low-grade systemic inflammation is associated with insulin resistance, hsCRP is a strong predictor for the development of type 2 diabetes.