1Tatemoto K,Takayama K,Zou MX,et al. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept,2001,99:87-92.
2Carroll AM,Selby TL, Palkovits M, et al. Distribution of mRNA encoding B78/apj,the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochim Biophys Acta, 2000,492 : 72-80.
3Foldes G, Horkay F, Szokodi I, et al. Circulating and cardiac levels of apelin,the novel ligand of the orphan receptor APJ.in patients with heart failure. Biochem Biophy Res Commun.2003. 308: 480-485.
4Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Regul Pept, 2004,118 : 119-125.
5Medhurst AD,Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. Neurochem, 2003, 84: 1162-1172.
6Vickers C, Hales P, Kaushik V, et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. Biol Chem 2002,277 : 14838-14843.
7Rice GI, Thomas DA, Grant PJ, et al. Evaluation of angiotensinconverting enzyme (ACE),its homologue ACE2 and neprilysin in angiotensin peptide metabolism, Biochem J,2004,383:45-51.
8Boucher J, Masri B, Daviaud D, et al. Apelin a newly identified adipokine up-regulated by insulin and obesity. Endocrinology,2005, 146 : 1764-1771.
9Wei L,Hou X, Tatemoto K,et al. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul Pept, 2005,132: 27-32.
10Heinonen MV, Purhonen AK, Miettinen P, et al. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding, Regul Pept, 2005,130: 7-13.
2Tatemoto K,Hosoya M,Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J].Biochem Biophy Res Commun,1998,251(2):471-476.
4Ishida J,Hashimoto T,Hashimoto Y,et al.Regulatory roles for APJ,a seven-transmembrane receptor related to angiotensin-type1 receptor in blood pressure in vivo[J].J Biol Chem,2004,279(25):26274-26279.
5Lee DK,Saldivia VR,Nguyen T,et al.Modification of the terminal residue of apelin-13 antagonizes its hypotensive action[J].Endocrinology,2005,146(1):231-236.
