胰岛素短期强化治疗对血、尿内皮素和尿白蛋白排泄率的影响

The effects of short-term insulin intensive treatment on serum and urine endothelin-1 and urine albumin excretion rate

对32例尿白蛋白排泄率(UAER)增高的初诊2型糖尿病患者行胰岛素短期强化治疗,血糖下降平稳2周后与治疗前比较,FBG、FA、HOMA-IR、HOMA-β、UAER、UET-1、SET-1的差异均有统计学意义,FBG、HOMA-IR分别与UAER、UET-1与SET-1呈显著的正相关。胰岛素强化治疗能改善高血糖引起的内皮功能障碍、降低UAER并改善胰岛素抵抗。

32 newly diagnosed type 2 diabetic patients who were in hyperglycemia and high urine albumin excretion rate（UAER）were treated with short-term intensive insulin treatment.FBG,FA,HOMA-IR,HOMA-β,UAER,UET-1 and SET-1 showed very significant differences between pre-and post-treatments after blood sugar declined for 2 weeks.FBG and HOMA-IR were significantly and positively correlated with UAER,UET-1,SET-1.Insulin intensive treatment can alleviate UAER,insulin resistance and the hyperglycemic endothelial dysfunction.