帕金森病模型研究进展

Recent Progress in Models of Parkinson's Disease

帕金森病(Parkinson’s disease,PD)是一种常见于中老年的神经退行性疾病,其特征性的病理改变为黑质纹状体多巴胺能神经元选择性缺失以及胞浆内涵物Lewy小体的形成。PD的发病机制目前尚不清楚,但已经明确环境因素和遗传因素在PD的发病中起重要作用。为阐明PD的病理生理机制,进一步探索新的治疗手段,迫切需要与PD密切相似的模型。本文将就目前发展的各种PD模型做一综述。

Parkinson＇s disease （PD） is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. The pathology of PD is typified by the presence of cytoplasmic inclusions （Lewy bodies ） containing a-synuclein and ubiquitin. The pathogenesis of PD is not completely understood but environmental and genetic factors are thought to play important roles. To understand the pathophysiology of PD, and to develop novel therapies for improved symptomatic management, it is important to have relevant disease models. In this review, we summarize the available in vivo and in vitro models of PD and discuss their value.