YB-1与肿瘤发生及治疗

YB-1, Tumorogenesis and Cancer Therapy

Y-box结合蛋白(Y-box binding protein,YB)是一类广泛存在于从低等到高等多种生物中的蛋白质家族,在体内行使多种生物学功能.大量研究表明,YB-1作为该家族成员之一,与许多重要的生物大分子存在密切联系,并对细胞、组织和机体的生理机能产生重大影响.更为重要的是,YB-1在多种疾病,尤其是恶性肿瘤的发生和发展中也起到十分关键的作用,对癌细胞表型的维持及肿瘤多药耐药性(MDR)的产生具有全方位的影响.以YB-1为作用靶点的新型肿瘤治疗策略可望有效控制癌症患者病情恶化,改善耐药状况.现就对YB-1与肿瘤发生和发展之间关系的研究进展,以及针对YB-1治疗策略的制定作一评述和展望.

Y-box binding protein is a group of proteins that exist in a wide range, from low level to high level, of biologic species and they perform multiple biological functions. Numerous researches indicate that YB-1, as a member of the Y-box binding protein family, can interact with many important biological molecules and significantly influence the physiological function in organisms. More importantly, YB-1 also has a very profound role in relation to many diseases, especially to occurrence and development of cancer, and it can induce and maintain all the phenotypes and multiple drug resistance （MDR） of cancer cells. It is anticipated that a novel strategy of cancer treatment targeting YB-1 will effectively slow down the conditional deterioration and abrogate MDR in the cancer patients. The current progresses made in the YB-1 researches to its association with the occurrence/development of cancer were discussed and prospect on new strategies targeting YB-1 was provided.