angiopoietins家族与角膜新生血管形成的关系

Roles of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization

角膜新生血管形成是角膜疾患的难题之一，其发病机制尚未明确。血管生成素（Ang）与其受体Tie2结合后构成Ang／Tie2信号传导系统。该系统在血管生成与调节的过程中发挥重要作用。目前，眼科学界已取得一些新的关于Ang／Tie2信号系统在角膜新生血管形成方面的研究进展。本文旨在分析、归纳Ang家族及其受体的结构、功能以及Ang／Tie2信号系统在角膜新生血管发生机制中的作用。

Corneal neovascularization is one of the tough problems in the cornea diseases, but its pathogenesis is still unclear. Binding of angiopoietins family and its receptor Tie2 set up the signal transducting system of Ang/Tie2, which plays the important role in the angiogenesis and regulation. Recently, the study of the signal transducting system of Ang/Tie2 has archived some progression in the corneal neovascularization. So this article reviewed the advances of related role of angiopoietins family and its receptor in the pathogenesis and regulation of corneal neovascularization including the structure and function of angiopoietins and its receptor Tie2.