昆虫细胞程序性死亡的研究进展

Research progress in programmed cell death in insects

在昆虫发育和抵抗病原微生物的入侵过程中,细胞凋亡与自噬性死亡现象十分常见。昆虫细胞凋亡的研究已经取得了许多的成果,但是有关细胞自噬程序性死亡的研究还正在深入。昆虫细胞凋亡的信号通路至少有3条:一条类似于线虫细胞的凋亡信号通路,另一条类似于哺乳动物细胞的凋亡信号通路,还有一条不依赖于胱天蛋白酶的凋亡信号通路。在昆虫的多种组织细胞中,细胞凋亡与自噬程序性死亡在信号通路上存在互串(crosstalking),可以相互促进、抑制或替代。了解昆虫细胞程序性死亡对防治害虫具有一定的意义。

Cell apoptosis and autophagic cell death are common during insect development and resistance against pathogens. Insect cell apoptosis has been elucidated better than insect cell autophagic death. There are at least three signal transduction pathways in insect cell apoptosis ： the first one is similar to nematode apoptosis pathway, the second similar to that used by mammals, and the third independent on caspases. Although insect cell apoptosis is distinguished from insect cell autophagic death, the cross-talking may exist between both. The two types of cell death pathways can promote, inhibit or substitute each other in insect cells. It is of great significance in pest control to understand programmed cell death in insects.