摘要
以邻二氯苯为原料，经硝化、氟化、还原合成氟氯苯胺．对关键的第二步氟化进行了改进，用１８－冠－６作相转移催化剂，ＤＭＳＯ为溶剂，在（１９０±２）℃反应１ｈ，产率达８９．５％，三步总收率为７６．５％．
chloro 4 fluroaniline was synthesized from o dichlorobenze, via nitration,flurination and reduction.The key step,flurination was the major work for improvement.using 18 C 6 as PTC,DMSO as solvant,reacting at (190±2)℃ for 1 h,the yield reach 89.5%.The gross yield of three steps preparations was 76.5%.
出处
《郑州轻工业学院学报》
1997年第3期10-14,共5页
Journal of Zhengzhou Institute of Light Industry（Natural Science）
关键词
氟氯苯胺
冠醚
合成工艺
fluorides
crown ethers compounds
dimethylsulfoxide
