工业氟暴露对机体脂质过氧化作用的影响及“抗氟灵”干预作用的研究

Effects of Occupational Fluoride Exposure on Body Lipid Peroxidation and Intervention with“KangFuLing”

为了解氟暴露对工人机体脂质过氧化作用的影响以及“抗氟灵”的疗效，选接氟工人，分中毒组、接氟组和对照组，在服“抗氟灵”前后采血留尿测定血中ＬＰＯ、ＧＳＨ含量，ＧＳＨ－Ｐｘ、ＳＯＤ活性及尿氟、ＢＦ－４含量。结果可见服药前尿Ｆ－、血清ＬＰＯ中毒组和接氟组较对照组明显增高，尿ＢＦ－４、血ＧＳＨ、ＧＳＨ－Ｐｘ与ＳＯＤ与对照组未见显著差异。服药后ＢＦ－４、ＧＳＨ－Ｐｘ、ＳＯＤ比对照组显著升高，而尿Ｆ－、血ＬＰＯ升高与服药前比较变化不大。说明氟可使机体脂质过氧化作用增强，“抗氟灵”驱氟主要以ＢＦ－４形式排出，在体内氟负荷减轻时ＧＳＨ－Ｐｘ、ＳＯＤ抗氧化酶活性有代偿性增高，“抗氟灵”

In order to understand the effects of occupational exposure to fluoride on the body lipid peroxidation in workers and the therapeutic effects of“KangFuLing”(KFL),workers exposed to fluoride were selected and classified into three groups,i.e.,fluorosis group,exposure one and controls,and their blood and urine specimens were collected before and after administration of KFL for measuring levels of lipid peroxide(LPO),reduced glutathione(GSH),and activities of glutathione peroxidase(GSHPx)and superoxide dismutase(SOD)in blood and levels of fluoride and borax tetrafluoride(BF-4)in urine.Results showed that urine fluoride level and blood LPO level were significantly higher in fluorosis and exposure groups than those in controls before administration of KFL.There was no significant difference in urine BF-4 level and activities of GSHPx and SOD between fluorosis and exposure groups and controls before administration of KFL.And,urine BF-4 level and activities of GSHPx and SOD increased more significantly in fluorosis and exposure groups than those in controls after administration of KFL,but little change in urine BF-4 and blood LPO,between before and after administration of KFL,could be found.It indicated that fluoride could strengthen the body lipid peroxidation and fluorine could be eliminated by KFL in a form of BF-4. And ,when fluorine burden in the body decreased,activities of GSHPx and SOD antioxidase increased as compensation.KFL had certain effects in intervening the body damage caused by fluoride.