血清LDL-VLDL-GGT测定对肝癌鉴别诊断意义的探讨

The studies on determination of serum LDL-VLDL-GGT in the differential diagnosis of liver cancer

本文以磷钨酸－氯化镁作沉淀剂，速率法测定血清低密度脂蛋白，极低密度脂蛋白结合的ｒ－谷氨酰转移酶（ＬＤＬ－ＶＬＤＬ－ＧＧＴ）占总ＧＧＴ的百分比。对临床２６例肝癌、１８例肝硬化、２２例慢性肝炎、１４例其他恶性肿瘤、１６例ＧＧＴ升高的非肝脏疾病及５０例健康人进行了检测，结果表明：肝癌组明显高于其他各组，差异显著（Ｐ＜０．０１）。肝脏疾病升高幅度：肝癌＞肝硬化＞慢性肝炎，且每两者间有显著差异（Ｐ＜０．０１）。其他恶性肿瘤组及非肝脏疾病组与健康人组无显著差异（Ｐ＞０．０５）。

The proportion of GGT complexed with low density lipoproteins plus very-low density lipoproteins in total GGT in serum is determinated with ratio colorimetery,sodium phosphotungstate and MgCl2 as precipitation.26 patients with liver cancer,18 with liver cirrhosis,22 with chronic hepatitis,14 with the other malignant tumors,16 with non-hepatobiliary disease of high GGT and 50 healthy subjects have been evaluated.The rusults show:that the liver cancer group is remarkbly higher than other groups (p<001).For hepatic deseases:liver cancer group>liver cirrhosis group>chronic hepatitis group,and the differences between each two groups are very significant(p<001).The difference of healthy subject from non-hepatobiliary desease gruop and the other malignant tumor group is insignificant(p>0.05).